{"id":6414,"date":"2022-10-14T15:48:45","date_gmt":"2022-10-14T19:48:45","guid":{"rendered":"https:\/\/clariowebstg.wpengine.com\/?post_type=landing-page&#038;p=6414"},"modified":"2025-04-23T12:58:28","modified_gmt":"2025-04-23T16:58:28","slug":"meet-your-e14-regulatory-requirements-early-with-epqt","status":"publish","type":"landing-page","link":"https:\/\/clario.com\/meet-your-e14-regulatory-requirements-early-with-epqt\/","title":{"rendered":"Meet your E14 regulatory requirements early with EPQT"},"content":{"rendered":"<div class=\"clario-section\">\n  <div class=\"container\">\n      \n<div class=\"row\">\n\t\n\n<div class=\"col-12 col-md-4 order-md-2\">\n\t\t\t\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"477\" height=\"476\" src=\"https:\/\/clario.com\/wp-content\/uploads\/2022\/04\/Cardiac-safety-ECG-header.png\" alt=\"Doctor hands with cardiogram chart\" class=\"wp-image-4605\" srcset=\"https:\/\/clario.com\/wp-content\/uploads\/2022\/04\/Cardiac-safety-ECG-header.png 477w, https:\/\/clario.com\/wp-content\/uploads\/2022\/04\/Cardiac-safety-ECG-header-300x300.png 300w\" sizes=\"auto, (max-width: 477px) 100vw, 477px\" \/><\/figure>\n\n\t<\/div>\n\n\n\n<div class=\"col-12 col-md-8 order-md-1\">\n\t\t\t\n\n<h4 class=\"wp-block-heading\">The Early Precision QT approach<\/h4>\n\n\n\n<h1 class=\"wp-block-heading\" id=\"h-meet-your-e14-regulatory-requirements-early-with-epqt\">Meet your E14 regulatory requirements early with EPQT<\/h1>\n\n\n\n<p>Careful assessment of QT and other ECG parameters in clinical trials is essential for ensuring cardiac safety. Therefore, small molecule compounds in development must undergo rigorous testing for their potential to prolong the QT interval on ECG as defined in the ICH E14 Guidance. The historical approach, Thorough QT (TQT) conducted in late phase, increases the risk of losing time and money.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"#replace-your-traditional-tqt-study\">Scroll<strong> \u2193 <\/strong><\/a><\/div>\n<\/div>\n\n\t<\/div>\n\n<\/div>\n\n  <\/div>\n<\/div>\n\n\n<div class=\"clario-section light-grey-50\">\n  <div class=\"container\">\n      \n<div class=\"row\">\n\t\n\n<div class=\"col-12 col-md-9\">\n\t\t\t\n\n<h2 class=\"wp-block-heading\" id=\"replace-your-traditional-tqt-study\">Replace your traditional TQT study<\/h2>\n\n\n\n<p>ECGs collected and analyzed during routine early phase studies using EPQT can provide reliable cardiac safety information that replaces the data historically derived from high-cost TQT studies.<\/p>\n\n\t<\/div>\n\n<\/div>\n\n\n<div class=\"row\">\n\t\n\n<div class=\"col-12 col-md-6\">\n\t\t\t\n\n<div class=\"wp-block-group white p-1 h-100\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group p-1 mb-2 h-100 dark-purple\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<h5 class=\"wp-block-heading has-text-align-center\" id=\"h-know-qt-risk-earlier\"><strong>Know QT risk earlier<\/strong><\/h5>\n<\/div><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img decoding=\"async\" src=\"https:\/\/clario.com\/wp-content\/uploads\/2022\/10\/Clock-24hours-v2.svg\" alt=\"\" class=\"wp-image-6613\" style=\"width:76px;height:77px\"\/><\/figure><\/div>\n\n\n<p class=\"has-text-align-center mt-1\">Obtain precise, actionable data earlier in the drug development process and proceed with confidence.<\/p>\n<\/div><\/div>\n\n\t<\/div>\n\n\n\n<div class=\"col-12 col-md-6\">\n\t\t\t\n\n<div class=\"wp-block-group p-1 white h-100\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group p-1 mb-2 h-100 purple-c\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<h5 class=\"wp-block-heading has-text-align-center\" id=\"h-potentially-save-millions\"><strong>Potentially save millions<\/strong><\/h5>\n<\/div><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img decoding=\"async\" src=\"https:\/\/clario.com\/wp-content\/uploads\/2022\/10\/Money-Icon-RGB.svg\" alt=\"\" class=\"wp-image-6612\" style=\"width:79px;height:80px\"\/><\/figure><\/div>\n\n\n<p class=\"has-text-align-center mt-1\">Demonstrate QT effect in Phase I when assessments can be significantly less expensive than in late phase.<\/p>\n<\/div><\/div>\n\n\t<\/div>\n\n<\/div>\n\n  <\/div>\n<\/div>\n\n\n<div class=\"clario-section\">\n  <div class=\"container\">\n      \n\n<h2 class=\"wp-block-heading has-text-align-center mb-0 pb-0\" id=\"h-with-epqt-sponsors-can-meet-ich-e14-earlier-in-development\">With EPQT, sponsors can meet ICH E14 earlier in development<\/h2>\n\n\n\n<iframe frameborder=\"0\" src=\"https:\/\/clario.com\/clario-epqt-interactive-experience-infographic\/EPQT-interactive-comparison-experience.html\" class=\"\" style=\"width:100%;max-width:100%;height:650px\"><\/iframe>\n\n\n<div class=\"row\">\n\t\n\n<div class=\"col-12 col-md-9\">\n\t\t\t\n<div class=\"clario-accordion accordion row \" id=\"accordion-accordion_6931316f085ec\">\n\n        <div class=\"clario-accordion-title col-12\" id=\"accordion-heading-b010a9dc\">\n            <h3 class=\"h4\" role=\"button\" data-toggle=\"collapse\" data-target=\"#accordion-content-b010a9dc\" aria-expanded=\"false\" aria-controls=\"accordion-content-1\">\n                Disclaimer\n            <\/h3>\n        <\/div>\n        <div class=\"clario-accordion-content collapse col-12\" aria-labelledby=\"accordion-heading-b010a9dc\" id=\"accordion-content-b010a9dc\" data-parent=\"#accordion-accordion_6931316f085ec\">\n            <p>In either case this result is an important component of the totality of evidence assessment of the risk of QT prolongation. The overall assessment of risk of QT prolongation includes nonclinical data, the time course of QT prolongation, the magnitude of QT prolongation, categorical analyses of outliers, and certain adverse events in patients that can signal potential proarrhythmic effects.<\/p>\n        <\/div><\/div>\n\n\t<\/div>\n\n<\/div>\n\n  <\/div>\n<\/div>\n\n\n<div class=\"clario-section clario-cta clario-cta-layout-standard  purple show-bg-pixel \">\n  <div class=\"container\">\n    <div class=\"row align-items-md-center\">\n        <div class=\"clario-cta-content col-md-6 offset-md-1 col-10\"><p class=\"h2\">Minimize risk and make smarter decisions<\/p><p><p>Have confidence in your data and execute safer studies with Clario&#8217;s Early Precision QT methodology (EPQT). <a href=\"https:\/\/clario.com\/wp-content\/uploads\/2022\/04\/Clario_White-paper_EPQT-24MAR2022.pdf\">Download the white paper<\/a> to discover the benefits of assessing cardiac safety in Phase 1 studies.<\/p>\n<\/p><\/div><div class=\"cta-buttons offset-md-1 col-md-4 col-10\"><div class=\"clario-cta-action\"><a href=\"#popup-1\" class=\"button cta-1 \">Talk to a specialist<\/a><\/div><\/div>    <\/div>\n  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assessment of QT and other ECG parameters in clinical trials is essential for ensuring cardiac safety."]},"_links":{"self":[{"href":"https:\/\/clario.com\/wp-json\/wp\/v2\/landing-page\/6414","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/clario.com\/wp-json\/wp\/v2\/landing-page"}],"about":[{"href":"https:\/\/clario.com\/wp-json\/wp\/v2\/types\/landing-page"}],"version-history":[{"count":0,"href":"https:\/\/clario.com\/wp-json\/wp\/v2\/landing-page\/6414\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/clario.com\/wp-json\/wp\/v2\/media\/2633"}],"wp:attachment":[{"href":"https:\/\/clario.com\/wp-json\/wp\/v2\/media?parent=6414"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}