{"id":5072,"date":"2022-05-31T03:32:22","date_gmt":"2022-05-31T07:32:22","guid":{"rendered":"https:\/\/clariowebstg.wpengine.com\/?page_id=5072"},"modified":"2025-07-16T14:50:09","modified_gmt":"2025-07-16T18:50:09","slug":"phase-i-tqt-cardiac-assessment","status":"publish","type":"solutions","link":"https:\/\/clario.com\/solutions\/cardiac-solutions\/phase-i-tqt-cardiac-assessment\/","title":{"rendered":"Phase I\/TQT Cardiac Assessment"},"content":{"rendered":"<div class=\"clario-anchor-navigation sticky-top \">\n  <div class=\"container\">\n    <div class=\"row\">\n      <a href=\"#overview\" class=\"button active nav-link col-auto\">Overview<\/a><a href=\"#detail\" class=\"button nav-link col-auto\">Detail<\/a><a href=\"#resources\" class=\"button nav-link col-auto\">Resources<\/a><a href=\"#publications\" class=\"button nav-link col-auto\">Publications<\/a>            <button class=\"control arrow closed\" aria-label=\"Toggle\"><\/button>\n    <\/div>\n  <\/div>\n<\/div>\n\n<script type=\"text\/javascript\">\n  jQuery(window).on(\"load\", function() {\n    Clario.AnchorNavigation.run();\n  });\n<\/script>\n\n\n<div class=\"clario-section pt-3 pb-3\">\n  <div class=\"container\">\n      \n<div class=\"row\">\n\t\n\n<div class=\"col-12 col-md-7\">\n\t\t\t\n\n<figure class=\"wp-block-embed is-type-video is-provider-vimeo wp-block-embed-vimeo wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"Clario Cardiac Safety - Early Precision\" src=\"https:\/\/player.vimeo.com\/video\/760320767?dnt=1&amp;app_id=122963\" width=\"640\" height=\"360\" frameborder=\"0\" allow=\"autoplay; fullscreen; picture-in-picture; clipboard-write; encrypted-media; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\"><\/iframe>\n<\/div><\/figure>\n\n\t<\/div>\n\n\n\n<div class=\"col-12 col-md-5\">\n\t\t\t<div class=\"h-100 d-flex flex-column justify-content-start\">\n\t\t\t\n\n<h2 class=\"wp-block-heading\" id=\"overview\">Overview<\/h2>\n\n\n\n<p>Receive precise and cost-effective QT assessments with Early Precision QT (EPQT). Quality QT\/QTc data is imperative in today\u2019s competitive R&amp;D market. Clario supported 70% of all new drug approvals from 2019-2020 offering a full range of support &#8211; from study design through submission &#8211; for formal Thorough QT studies and for assessing QT safety in clinical trials for which a <a href=\"https:\/\/clario.com\/resources\/articles\/a-pathway-for-replacing-costly-tqt-studies\/\">traditional TQT <\/a>study is not feasible.<\/p>\n\n\n\n<p>Watch this video for more information.<\/p>\n\n\t\t<\/div>\n\t<\/div>\n\n<\/div>\n\n  <\/div>\n<\/div>\n\n\n<div class=\"clario-section clario-cta clario-cta-layout-standard  dark-purple show-bg-pixel \">\n  <div class=\"container\">\n    <div class=\"row align-items-md-center\">\n        <div class=\"clario-cta-content col-md-6 offset-md-1 col-10\"><p class=\"h2\">Learn how to meet your ICH E14 regulatory requirements early with EPQT<\/p><\/div><div class=\"cta-buttons offset-md-1 col-md-4 col-10\"><div class=\"clario-cta-action\"><a href=\"\/meet-your-e14-regulatory-requirements-early-with-epqt\/\" class=\"button cta-1 \">View infographic<\/a><\/div><\/div>    <\/div>\n  <\/div>\n<\/div>\n\n\n<div class=\"clario-section light-grey-50\">\n  <div class=\"container\">\n      \n<div class=\"row\">\n\t\n\n<div class=\"col-12 col-md-9\">\n\t\t\t\n\n<h2 class=\"wp-block-heading\" id=\"detail\">Product detail<\/h2>\n\n\n\n<p>Confidently implement EPQT in your Phase 1 studies to enable earlier, more precise and cost-effective cardiac safety assessments and potentially qualify for a TQT waiver. The EPQT methodology was clinically proven in a comprehensive clinical trial, which concluded that ECGs collected and analyzed during routine early-phase studies could reliably provide cardiac safety information typically derived from dedicated TQT studies.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Understand QT and other ECG effects of a new drug and ensure compliance with ICH E14 Regulation<\/li>\n\n\n\n<li>Obtain reliable, precise data earlier in development using clinically proven proprietary Early Precision QT methodology<\/li>\n\n\n\n<li>Navigate unexpected issues throughout your trial by collaborating with our Phase 1 Center of Excellence<\/li>\n\n\n\n<li>Partner with Clario Certified Sites who are well-trained and well-equipped&nbsp;to shorten study startup times and collect quality data<\/li>\n\n\n\n<li>Ensure promising drugs and therapies aren\u2019t eliminated due to inaccurate data<\/li>\n<\/ul>\n\n\t<\/div>\n\n<\/div>\n\n  <\/div>\n<\/div>\n\n\n<div class=\"clario-section\">\n  <div class=\"container\">\n      \n\n<h2 class=\"wp-block-heading\" id=\"resources\">Related resources<\/h2>\n\n\n  <div class=\"clario-collection clario-collection-select row  clario-collection-count-3\">\n                              <article class=\"mb-2 col-12 col-md-6 col-xl-3\">\n              <a href=\"https:\/\/clario.com\/wp-content\/uploads\/2023\/01\/2022-ECG-Evaluation-as-Part-of-the-Clinical-Pharmacology-Strategy-in-the-Development-of-New-Drugs.pdf\" target=\"_blank\" class=\"clario-thumb-resource clario-thumb clario-thumb-type-resource clario-thumb-type-post dark-purple\">\n    <span class=\"clario-thumb-category label\">White Paper<\/span>\n    <h4 class=\"clario-thumb-title\">ECG evaluation in early clinical trials<\/h4>\n    <div class=\"clario-thumb-row row\">\n      <div class=\"col-6 clario-thumb-icon\">\n        <img loading=\"lazy\" decoding=\"async\" width=\"36\" height=\"36\" class=\"clario-thumb-mian-image clario-thumb-rs-icon\" alt=\"Download icon\" src=\"https:\/\/clario.com\/wp-content\/themes\/clario-bootstrap\/media\/icons\/resource-download-icon-white.svg\">\n        <img loading=\"lazy\" decoding=\"async\" width=\"36\" height=\"36\" class=\"clario-thumb-hover-image clario-thumb-rs-icon\" alt=\"Download icon\" src=\"https:\/\/clario.com\/wp-content\/themes\/clario-bootstrap\/media\/icons\/resource-download-icon-white.svg\">\n      <\/div>\n      <div class=\"col-6 clario-thumb-link-text\"><span class=\"clario-thumb-link button primary\">Download<\/span><\/div>\n    <\/div>\n  <\/a>\n          <\/article>\n                  <article class=\"mb-2 col-12 col-md-6 col-xl-3\">\n              <a href=\"https:\/\/clario.com\/wp-content\/uploads\/2025\/01\/WhitePaper_CS_TheEPQTApproach_15Jan2025.pdf\" target=\"_blank\" class=\"clario-thumb-resource clario-thumb clario-thumb-type-resource clario-thumb-type-post dark-purple\">\n    <span class=\"clario-thumb-category label\">White Paper<\/span>\n    <h4 class=\"clario-thumb-title\">The early precision QT approach<\/h4>\n    <div class=\"clario-thumb-row row\">\n      <div class=\"col-6 clario-thumb-icon\">\n        <img loading=\"lazy\" decoding=\"async\" width=\"36\" height=\"36\" class=\"clario-thumb-mian-image clario-thumb-rs-icon\" alt=\"Download icon\" src=\"https:\/\/clario.com\/wp-content\/themes\/clario-bootstrap\/media\/icons\/resource-download-icon-white.svg\">\n        <img loading=\"lazy\" decoding=\"async\" width=\"36\" height=\"36\" class=\"clario-thumb-hover-image clario-thumb-rs-icon\" alt=\"Download icon\" src=\"https:\/\/clario.com\/wp-content\/themes\/clario-bootstrap\/media\/icons\/resource-download-icon-white.svg\">\n      <\/div>\n      <div class=\"col-6 clario-thumb-link-text\"><span class=\"clario-thumb-link button primary\">Download<\/span><\/div>\n    <\/div>\n  <\/a>\n          <\/article>\n                  <article class=\"mb-2 col-12 col-md-6 col-xl-3\">\n              <a href=\"https:\/\/clario.com\/resources\/downloads\/early-precision-qt\/\" class=\"clario-thumb-resource clario-thumb clario-thumb-type-resource clario-thumb-type-post dark-purple\">\n    <span class=\"clario-thumb-category label\">Datasheet<\/span>\n    <h4 class=\"clario-thumb-title\">Early precision QT<\/h4>\n    <div class=\"clario-thumb-row row\">\n      <div class=\"col-6 clario-thumb-icon\">\n        <img loading=\"lazy\" decoding=\"async\" width=\"36\" height=\"36\" class=\"clario-thumb-mian-image clario-thumb-rs-icon\" alt=\"Read icon\" src=\"https:\/\/clario.com\/wp-content\/themes\/clario-bootstrap\/media\/icons\/resource-read-icon-white.svg\">\n        <img loading=\"lazy\" decoding=\"async\" width=\"36\" height=\"36\" class=\"clario-thumb-hover-image clario-thumb-rs-icon\" alt=\"Read icon\" src=\"https:\/\/clario.com\/wp-content\/themes\/clario-bootstrap\/media\/icons\/resource-read-icon-white.svg\">\n      <\/div>\n      <div class=\"col-6 clario-thumb-link-text\"><span class=\"clario-thumb-link button primary\">Read<\/span><\/div>\n    <\/div>\n  <\/a>\n          <\/article>\n                          <\/div>\n\n  <\/div>\n<\/div>\n\n\n<div class=\"clario-section light-grey-50\">\n  <div class=\"container\">\n      \n<div class=\"row\">\n\t\n\n<div class=\"col-12 col-md-12\">\n\t\t\t\n\n<h2 class=\"wp-block-heading\" id=\"h-related-solutions\">Related solutions<\/h2>\n\n\n<div class=\"clario-collection clario-collection-summary clario-collection-resources clario-collection-type-solution row \"><article class=\"col-12 col-md-6 col-xl-4\">\n<a href=\"https:\/\/clario.com\/solutions\/cardiac-solutions\/arrhythmia\/\" class=\"clario-solution-thumb\">\n  <img loading=\"lazy\" decoding=\"async\" width=\"545\" height=\"265\" src=\"https:\/\/clario.com\/wp-content\/uploads\/2022\/05\/arrhythmia-featured.png\" class=\"attachment-medium size-medium wp-post-image\" alt=\"arrhythmia-featured\" \/>  <h3 class=\"clario-thumb-title\">Arrhythmia Analysis<\/h3>\n  <p>Collect continuous ECG data with certainty in site-based or decentralized clinical trials with our flexible technology solutions and patient-friendly devices.<\/p>\n  <span class=\"clario-thumb-link button primary\">Find out more<\/span>\n<\/a>\n      <\/article><article class=\"col-12 col-md-6 col-xl-4\">\n<a href=\"https:\/\/clario.com\/solutions\/cardiac-solutions\/blood-pressure-services\/\" class=\"clario-solution-thumb\">\n  <img loading=\"lazy\" decoding=\"async\" width=\"545\" height=\"265\" src=\"https:\/\/clario.com\/wp-content\/uploads\/2022\/11\/blood-pressure-featured.png\" class=\"attachment-medium size-medium wp-post-image\" alt=\"blood-pressure-featured\" \/>  <h3 class=\"clario-thumb-title\">Blood Pressure Services<\/h3>\n  <p>Collect and centrally analyze accurate, consistent, quality blood pressure data from site-based to decentralized trials.<\/p>\n  <span class=\"clario-thumb-link button primary\">Find out more<\/span>\n<\/a>\n      <\/article><article class=\"col-12 col-md-6 col-xl-4\">\n<a href=\"https:\/\/clario.com\/solutions\/cardiac-solutions\/ecg-phase-i-through-iv\/\" class=\"clario-solution-thumb\">\n  <img loading=\"lazy\" decoding=\"async\" width=\"545\" height=\"265\" src=\"https:\/\/clario.com\/wp-content\/uploads\/2022\/11\/ECG-featured.png\" class=\"attachment-medium size-medium wp-post-image\" alt=\"ECG-featured\" \/>  <h3 class=\"clario-thumb-title\">ECG \u2014 On-site to DCT and Phase I-IV<\/h3>\n  <p>Monitor every heartbeat with precision from anywhere to assess safety and efficacy throughout your site-based or decentralized clinical trial.<\/p>\n  <span class=\"clario-thumb-link button primary\">Find out more<\/span>\n<\/a>\n      <\/article><article class=\"col-12 col-md-6 col-xl-4\">\n<a href=\"https:\/\/clario.com\/solutions\/cardiac-solutions\/regulatory-consultation-and-statistical-analysis-expertise\/\" class=\"clario-solution-thumb\">\n  <img loading=\"lazy\" decoding=\"async\" width=\"545\" height=\"265\" src=\"https:\/\/clario.com\/wp-content\/uploads\/2022\/11\/Regulatory-featured.png\" class=\"attachment-medium size-medium wp-post-image\" alt=\"Regulatory-featured\" \/>  <h3 class=\"clario-thumb-title\">Regulatory Consultation and Statistical Analysis Expertise<\/h3>\n  <p>Leverage our industry key opinion leaders to understand the complex regulatory landscape while minimizing risk with confidence.<\/p>\n  <span class=\"clario-thumb-link button primary\">Find out more<\/span>\n<\/a>\n      <\/article>  <\/div>\n\t<\/div>\n\n<\/div>\n\n  <\/div>\n<\/div>\n\n\n<div class=\"clario-section\">\n  <div class=\"container\">\n      \n<div class=\"row\">\n\t\n\n<div class=\"col-12 col-md-9\">\n\t\t\t\n\n<h2 class=\"wp-block-heading\" id=\"publications\">Peer-reviewed journals<\/h2>\n\n\t<\/div>\n\n<\/div>\n\n\n  <div class=\"clario-collection clario-collection-select row  clario-collection-count-2\">\n                              <article class=\"mb-2 col-12 col-md-6 col-xl-4\">\n            <a href=\"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/full\/10.1002\/jcph.2309\" target=\"_blank\" rel=\"noopener\" class=\"clario-thumb clario-thumb-type-ep dark-purple\"><span class=\"clario-thumb-category label\">Peer-Reviewed<\/span><h3 class=\"clario-thumb-title\">The New S7B\/E14 Q&amp;A Document Provides Additional Opportunities to Replace the Thorough QT Study<\/h3><span class=\"clario-thumb-link button primary\">Read<\/span><\/a>          <\/article>\n                  <article class=\"mb-2 col-12 col-md-6 col-xl-4\">\n            <a href=\"https:\/\/clario.com\/wp-content\/uploads\/2022\/04\/Clario_White-paper_IQ-CSRC-Study-24MAR2022.pdf\" target=\"_blank\" class=\"clario-thumb clario-thumb-type-ep dark-purple\"><span class=\"clario-thumb-category label\">Peer-Reviewed<\/span><h3 class=\"clario-thumb-title\">Implications of the IQ-CRSC prospective study: Time to revise ICH E14<\/h3><span class=\"clario-thumb-link button primary\">Download<\/span><\/a>          <\/article>\n                          <\/div>\n\n  <\/div>\n<\/div>\n\n\n<div class=\"clario-section clario-cta clario-cta-layout-standard  purple show-bg-pixel \" id=customer >\n  <div class=\"container\">\n    <div class=\"row align-items-md-center\">\n        <div class=\"clario-cta-content col-md-6 offset-md-1 col-10\"><p class=\"h2\">Clario has supported 3,600+ early phase cardiac studies.<\/p><p><p>Let us support your next cardiac study.<\/p>\n<\/p><\/div><div class=\"cta-buttons offset-md-1 col-md-4 col-10\"><div class=\"clario-cta-action\"><a href=\"#popup-1\" class=\"button cta-1 \">Get started<\/a><\/div><\/div>    <\/div>\n  <\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Fulfill your ICH E14 requirement early, minimize risk and potentially reduce costs throughout your trial by collaborating with our Phase 1 Center of Excellence. [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/clario.com\/solutions\/cardiac-solutions\/phase-i-tqt-cardiac-assessment\/\">Read More&#8230;<span class=\"screen-reader-text\"> from Phase I\/TQT Cardiac Assessment<\/span><\/a><\/p>\n","protected":false},"featured_media":7028,"parent":5034,"menu_order":4,"template":"","tags":[121],"class_list":["post-5072","solutions","type-solutions","status-publish","has-post-thumbnail","hentry","tag-solutions"],"acf":[],"cp_meta_data":{"_dp_original":["4386"],"_edit_last":["7"],"_edit_lock":["1752691810:7"],"page_title":[""],"_page_title":["field_615dbd9cfca50"],"banner_image":["5234"],"_banner_image":["field_614c580034347"],"introduction":["Fulfill your ICH E14 requirement early, minimize risk and potentially reduce costs throughout your trial by collaborating with our Phase 1 Center of Excellence.\r\n"],"_introduction":["field_614c581e34348"],"_yoast_wpseo_focuskeywords":["[{\"keyword\":\"Early Precision QT Certified Site\",\"score\":61},{\"keyword\":\"TQT Waiver Certified Site\",\"score\":61},{\"keyword\":\"Clario Certified Site\",\"score\":61},{\"keyword\":\"ICH E14 Certified Site\",\"score\":61}]"],"_yoast_wpseo_keywordsynonyms":["[\"\",\"\",\"\",\"\",\"\"]"],"_yoast_wpseo_estimated-reading-time-minutes":["2"],"show_header_pixel":["1"],"_show_header_pixel":["field_6221d6b147ede"],"_yoast_wpseo_focuskw":["EPQT Phase 1 Certified Site"],"_yoast_wpseo_metadesc":["Clario's clinically proven early precision QT methodology fulfills ICH E14 requirement early minimizing risk and potentially reducing costs through clinical trials."],"_yoast_wpseo_linkdex":["59"],"_thumbnail_id":["7028"],"solutions":["a:4:{i:0;s:4:\"5069\";i:1;s:4:\"5070\";i:2;s:4:\"5071\";i:3;s:4:\"5073\";}"],"_solutions":["field_61eac16edee33"],"solutions_category":["a:1:{i:0;s:4:\"5034\";}"],"_solutions_category":["field_61eac09d5e59c"],"therapeutic_areas":["a:1:{i:0;s:4:\"3758\";}"],"_therapeutic_areas":["field_61eac19284449"],"call_to_action_button":["1"],"_call_to_action_button":["field_629888a6435a9"],"cta_btn_text":["Get started"],"_cta_btn_text":["field_62984e409758b"],"cta_btn_url":["#popup-1"],"_cta_btn_url":["field_62984e699758c"],"cta_btn_style":["cta-1"],"_cta_btn_style":["field_62986b9c7c2ee"],"introduction_paragraph":["Every millisecond of precision counts when assessing cardiac safety."],"_introduction_paragraph":["field_629ee2f209b6b"],"cta_url_open_new_tab":["0"],"_cta_url_open_new_tab":["field_629dce361d7e6"],"_yoast_indexnow_last_ping":["1752691750"],"popup_id":["#popup-1"],"_popup_id":["field_62bbe75b187ac"],"cta_btn_css_class":[""],"_cta_btn_css_class":["field_62bab8d5adfa4"],"show_popup":["1"],"_show_popup":["field_62b1aec56dcb5"],"popup_box_title":["Talk to a specialist about products or services."],"_popup_box_title":["field_62b1abd448f4a"],"popup_box_id":["popup-1"],"_popup_box_id":["field_62b1ab70ff7f5"],"popup_emcode":["hbspt.forms.create({\r\n\tregion: \"na1\",\r\n\tportalId: \"7229613\",\r\n\tformId: \"7d795cb7-102e-455e-ae62-f5bcaf04c028\"\r\n});"],"_popup_emcode":["field_62b1abaeff7f6"],"popup_header_sub_text":["NOT WHAT YOU'RE LOOKING FOR?"],"_popup_header_sub_text":["field_62b1ac3ef181a"],"customer_support_button_text":["Customer Support"],"_customer_support_button_text":["field_62ba932df2b59"],"customer_support_button_url":["\/contact\/customer-support\/"],"_customer_support_button_url":["field_62ba933ff2b5a"],"careers_button_text":["Careers"],"_careers_button_text":["field_62ba948c01eb8"],"Careers_button_url":["\/careers\/"],"_Careers_button_url":["field_62ba948f01eb9"],"locations_button_text":["Locations"],"_locations_button_text":["field_62ba94d901eba"],"locations_button_url":["\/contact\/#our_locations"],"_locations_button_url":["field_62ba94dc01ebb"],"media_contact_button_text":["Media Contact"],"_media_contact_button_text":["field_62ba951501ebc"],"media_contact_button_url":["mailto:media@clario.com"],"_media_contact_button_url":["field_62ba951701ebd"],"_yoast_wpseo_wordproof_timestamp":[""],"display_prefooter":["hide"],"_display_prefooter":["field_61641783f0f7c"],"_yoast_wpseo_content_score":["30"],"_oembed_14aff0efac0a57796a3695bb20925023":["<iframe title=\"Clario Cardiac Safety - Early Precision\" src=\"https:\/\/player.vimeo.com\/video\/760320767?h=d13ff81e09&amp;dnt=1&amp;app_id=122963\" width=\"640\" height=\"360\" frameborder=\"0\" allow=\"autoplay; 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