{"id":12973,"date":"2025-07-02T10:06:25","date_gmt":"2025-07-02T14:06:25","guid":{"rendered":"https:\/\/clariowebstg.wpengine.com\/?post_type=therapeutic-areas&#038;p=12973"},"modified":"2025-07-28T12:24:28","modified_gmt":"2025-07-28T16:24:28","slug":"pain-disorders","status":"publish","type":"therapeutic-areas","link":"https:\/\/clario.com\/therapeutic-areas\/neuroscience\/pain-disorders\/","title":{"rendered":"Pain Disorders"},"content":{"rendered":"<div class=\"clario-anchor-navigation sticky-top \">\n  <div class=\"container\">\n    <div class=\"row\">\n      <a href=\"#overview\" class=\"button active nav-link col-auto\">Overview<\/a><a href=\"#solutions-and-expertise\" class=\"button nav-link col-auto\">Solutions and expertise<\/a>            <button class=\"control arrow closed\" aria-label=\"Toggle\"><\/button>\n    <\/div>\n  <\/div>\n<\/div>\n\n<script type=\"text\/javascript\">\n  jQuery(window).on(\"load\", function() {\n    Clario.AnchorNavigation.run();\n  });\n<\/script>\n\n\n<div class=\"clario-section light-grey-50\">\n  <div class=\"container\">\n      \n<div class=\"row\">\n\t\n\n<div class=\"col-12 col-md-9\">\n\t\t\t\n\n<p class=\"mb-0 has-pattern-4-color has-text-color\" id=\"overview\" style=\"font-style:normal;font-weight:600\">OVERVIEW<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-solving-the-complexities-of-pain-research-nbsp\">Solving the complexities of pain research&nbsp;<\/h2>\n\n\n\n<p>At Clario, we combine validated eCOA strategies, advanced imaging biomarkers, and proven placebo mitigation methods to deliver reliable, high-quality data. Our integrated solutions don&#8217;t just support pain trials &#8211; they help elevate them, so sponsors can make confident evidence-based decisions.<\/p>\n\n\t<\/div>\n\n<\/div>\n\n  <\/div>\n<\/div>\n\n\n<div class=\"clario-section\">\n  <div class=\"container\">\n      \n<div class=\"row\">\n\t\n\n<div class=\"col-12 col-md-12\">\n\t\t\t\n\n<p class=\"mb-0 has-pattern-4-color has-text-color\" id=\"solutions-and-expertise\" style=\"font-style:normal;font-weight:600\">SOLUTIONS AND EXPERTISE<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-comprehensive-solutions-for-pain-trials-nbsp\">Comprehensive solutions for pain trials&nbsp;<\/h2>\n\n\t<\/div>\n\n<\/div>\n\n  <\/div>\n<\/div>\n\n\n<div class=\"clario-section pt-0 mt-0\">\n  <div class=\"container\">\n      \n<div class=\"row align-items-center\">\n\t\n\n<div class=\"col-12 col-md-6\">\n\t\t\t\n<div class=\"responsive-image-block\">\n    <div class=\"row justify-content-between align-items-center\">\n        <div class=\"col-12 mb-2 responsive-image\">\n            <div class=\"img-container img-container-desktop\">\n                                    <img decoding=\"async\" src=\"https:\/\/clario.com\/wp-content\/uploads\/2025\/06\/pain-ecoa-section-img.png\" class=\"default-pixel img-fluid\" height=\"auto\" width=\"auto\" alt=\"\">\n                            <\/div>\n            <div class=\"img-container img-container-mobile\">\n                                    <img decoding=\"async\" src=\"https:\/\/clario.com\/wp-content\/uploads\/2025\/06\/pain-ecoa-section-img.png\" class=\"default-pixel img-fluid\" height=\"auto\" width=\"auto\" alt=\"\">\n                            <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n\t<\/div>\n\n\n\n<div class=\"col-12 col-md-6\">\n\t\t\t\n\n<h3 class=\"wp-block-heading\" id=\"h-improve-data-accuracy-with-epro-and-ediaries\">Improve data accuracy with ePRO and eDiaries<\/h3>\n\n\n\n<p>Patient-reported outcomes (PROs) and daily diaries are essential for capturing treatment effects in pain studies, yet traditional methods can lead to incomplete or inaccurate data. Our eCOA solutions maintain data integrity, improve compliance, and streamline reporting.&nbsp;<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>eDiaries with timestamped, validated entries to meet FDA ALCOA standards<\/li>\n\n\n\n<li>Automated reminders to enhance patient adherence<\/li>\n\n\n\n<li>Real-time data monitoring for improved trial efficiency<\/li>\n<\/ul>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-secondary\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/clario.com\/solutions\/ecoa\/\">Explore our eCOA solutions<\/a><\/div>\n<\/div>\n\n\t<\/div>\n\n<\/div>\n\n  <\/div>\n<\/div>\n\n\n<div class=\"clario-section\">\n  <div class=\"container\">\n      \n<div class=\"row align-items-center\">\n\t\n\n<div class=\"col-12 col-md-6 order-md-2\">\n\t\t\t\n<div class=\"responsive-image-block\">\n    <div class=\"row justify-content-between align-items-center\">\n        <div class=\"col-12 mb-2 responsive-image\">\n            <div class=\"img-container img-container-desktop\">\n                                    <img decoding=\"async\" src=\"https:\/\/clario.com\/wp-content\/uploads\/2025\/06\/pain-pain-scales-section-img-1000x875.png\" class=\"default-pixel img-fluid\" height=\"auto\" width=\"auto\" alt=\"\">\n                            <\/div>\n            <div class=\"img-container img-container-mobile\">\n                                    <img decoding=\"async\" src=\"https:\/\/clario.com\/wp-content\/uploads\/2025\/06\/pain-pain-scales-section-img-1000x875.png\" class=\"default-pixel img-fluid\" height=\"auto\" width=\"auto\" alt=\"\">\n                            <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n\t<\/div>\n\n\n\n<div class=\"col-12 col-md-6\">\n\t\t\t\n\n<h3 class=\"wp-block-heading\" id=\"h-select-the-right-pain-scales-and-mitigate-placebo-response\">Select the right pain scales and mitigate placebo response<\/h3>\n\n\n\n<p>Pain manifests in diverse ways, making endpoint selection complex. Our eCOA scientists provide expert guidance in choosing validated pain scales, while our proven placebo response mitigation strategies help improve signal detection and reduce variability.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Expert recommendations on validated pain assessment tools<\/li>\n\n\n\n<li>Investigator training to minimize placebo response impact<\/li>\n\n\n\n<li>Scientifically backed mitigation strategies that enhance trial success<\/li>\n<\/ul>\n\n\t<\/div>\n\n<\/div>\n\n  <\/div>\n<\/div>\n\n\n<div class=\"clario-section\">\n  <div class=\"container\">\n      \n<div class=\"row align-items-center\">\n\t\n\n<div class=\"col-12 col-md-6\">\n\t\t\t\n<div class=\"responsive-image-block\">\n    <div class=\"row justify-content-between align-items-center\">\n        <div class=\"col-12 mb-2 responsive-image\">\n            <div class=\"img-container img-container-desktop\">\n                                    <img decoding=\"async\" src=\"https:\/\/clario.com\/wp-content\/uploads\/2025\/06\/pain-mi-section-img.png\" class=\"default-pixel img-fluid\" height=\"auto\" width=\"auto\" alt=\"\">\n                            <\/div>\n            <div class=\"img-container img-container-mobile\">\n                                    <img decoding=\"async\" src=\"https:\/\/clario.com\/wp-content\/uploads\/2025\/06\/pain-mi-section-img.png\" class=\"default-pixel img-fluid\" height=\"auto\" width=\"auto\" alt=\"\">\n                            <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n\t<\/div>\n\n\n\n<div class=\"col-12 col-md-6\">\n\t\t\t\n\n<h3 class=\"wp-block-heading\" id=\"h-enhance-trial-design-with-advanced-imaging-and-biomarkers\">Enhance trial design with advanced imaging and biomarkers<\/h3>\n\n\n\n<p>Pain perception is influenced by complex neurological pathways. Our medical imaging experts leverage MRI, PET, and other advanced imaging modalities to assess brain function and biomarkers, providing deeper insights into treatment effects.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Brain imaging to identify pain-related biomarkers<\/li>\n\n\n\n<li>Advanced data analysis to support regulatory decision-making<\/li>\n\n\n\n<li>Reliable imaging endpoints for stronger clinical evidence<\/li>\n<\/ul>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-secondary\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/clario.com\/solutions\/medical-imaging\/\">Discover our imaging capabilities<\/a><\/div>\n<\/div>\n\n\t<\/div>\n\n<\/div>\n\n  <\/div>\n<\/div>\n\n\n<div class=\"clario-section\">\n  <div class=\"container\">\n      \n<div class=\"row align-items-center\">\n\t\n\n<div class=\"col-12 col-md-6 order-md-2\">\n\t\t\t\n<div class=\"responsive-image-block\">\n    <div class=\"row justify-content-between align-items-center\">\n        <div class=\"col-12 mb-2 responsive-image\">\n            <div class=\"img-container img-container-desktop\">\n                                    <img decoding=\"async\" src=\"https:\/\/clario.com\/wp-content\/uploads\/2025\/06\/biotech-page-img-bottom.png\" class=\"default-pixel img-fluid\" height=\"auto\" width=\"auto\" alt=\"\">\n                            <\/div>\n            <div class=\"img-container img-container-mobile\">\n                                    <img decoding=\"async\" src=\"https:\/\/clario.com\/wp-content\/uploads\/2025\/06\/biotech-page-img-bottom.png\" class=\"default-pixel img-fluid\" height=\"auto\" width=\"auto\" alt=\"\">\n                            <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n\t<\/div>\n\n\n\n<div class=\"col-12 col-md-6\">\n\t\t\t\n\n<h3 class=\"wp-block-heading\" id=\"h-protect-trial-integrity-with-expert-clinical-adjudication\">Protect trial integrity with expert clinical adjudication<\/h3>\n\n\n\n<p>Pain trials often require independent evaluation of safety events and treatment efficacy. Our Clinical Event Committee (CEC) provides expert adjudication to provide standardized, objective and reliable assessments.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Blinded, independent expert review of clinical outcome and safety events<\/li>\n\n\n\n<li>Standardized classification for regulatory compliance<\/li>\n\n\n\n<li>Comprehensive data integrity for trial success<\/li>\n<\/ul>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-secondary\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/clario.com\/solutions\/trial-enablement\/clinical-adjudication\/\">Learn about our clinical adjudication services<\/a><\/div>\n<\/div>\n\n\t<\/div>\n\n<\/div>\n\n  <\/div>\n<\/div>\n\n\n<div class=\"clario-section light-grey-50 pt-0 pb-1\">\n  <div class=\"container\">\n      \n<div class=\"row my-3 justify-content-center\">\n\t\n\n<div class=\"col-12 col-md-10 pt-3\">\n\t\t\t\n\n<h2 class=\"wp-block-heading has-text-align-center\" id=\"h-partner-with-clario-for-reliable-actionable-data\">Partner with Clario for reliable, actionable data<\/h2>\n\n\n\n<h3 class=\"wp-block-heading has-text-align-center\" id=\"h-let-s-work-together-to-advance-pain-research-with-confidence\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-pink-color\">Let&#8217;s work together to advance pain research with confidence<\/mark><\/h3>\n\n\n\n<p class=\"has-text-align-center\">With extensive experience in pain trials, we provide the expertise, technology, and regulatory support needed to overcome common challenges. From optimizing eCOA strategies to leveraging advanced imaging and safety monitoring, we help support your trial to deliver meaningful, high-quality results.<\/p>\n\n\n\n<div class=\"wp-block-buttons btn-sm-center is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-16018d1d wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-secondary is-style-cta-1\"><a class=\"wp-block-button__link wp-element-button\" href=\"#popup-1\">Get started<\/a><\/div>\n<\/div>\n\n\t<\/div>\n\n<\/div>\n\n  <\/div>\n<\/div>\n\n\n<div class=\"clario-section\">\n  <div class=\"container\">\n      \n<div class=\"clario-accordion-element clario-accordion accordion row \" id=\"accordion-69312bd091bd8\">\n<div class=\"clario-accordion-title col-12\" id=\"accordion-heading-5a89d58a\">\n      <h3 class=\"h4\" role=\"button\" data-toggle=\"collapse\" data-target=\"#accordion-content-5a89d58a\" aria-expanded=\"false\" aria-controls=\"accordion-content-0\">References<\/h4>\n    <\/div>\n    <div class=\"clario-accordion-content collapse col-12\" aria-labelledby=\"accordion-heading-5a89d58a\" id=\"accordion-content-5a89d58a\" data-parent=\"#accordion-69312bd091bd8\">\n\n<ol class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.iasp-pain.org\/resources\/fact-sheets\/high-impact-chronic-pain\/\">High-Impact Chronic Pain &#8211; International Association for the Study of Pain (IASP)<\/a><\/li>\n<\/ol>\n\n<\/div><\/div>\n\n  <\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p> [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/clario.com\/therapeutic-areas\/neuroscience\/pain-disorders\/\">Read More&#8230;<span class=\"screen-reader-text\"> from Pain Disorders<\/span><\/a><\/p>\n","protected":false},"featured_media":0,"parent":5024,"menu_order":0,"template":"","tags":[],"class_list":["post-12973","therapeutic-areas","type-therapeutic-areas","status-publish","hentry"],"acf":[],"cp_meta_data":{"bt_post_experiments_editor":["gutenberg"],"page_title":[""],"_page_title":["field_615dbd9cfca50"],"select_hero_section_type":["image"],"_select_hero_section_type":["field_63e9c1ac237af"],"banner_image":["13003"],"_banner_image":["field_614c580034347"],"show_header_pixel":["1"],"_show_header_pixel":["field_6221d6b147ede"],"introduction":["Chronic pain is a pervasive health issue, <strong>affecting approximately 20% of adults worldwide<\/strong> - around 1.5 billion people enduring persistent pain that often impairs quality of life and functional abilities.<small><sup>1<\/sup><\/small>"],"_introduction":["field_614c581e34348"],"introduction_paragraph":["<em>\"Pain trials demand more than standard tools - they require a nuanced, scientifically grounded approach to capture complex, subjective experiences.\"<\/em> <br><br>Todd Rudo, M.D.<br>Chief Medical Officer at Clario"],"_introduction_paragraph":["field_629ee2f209b6b"],"call_to_action_button":["1"],"_call_to_action_button":["field_629888a6435a9"],"cta_btn_css_class":[""],"_cta_btn_css_class":["field_62bab8d5adfa4"],"display_prefooter":["hide"],"_display_prefooter":["field_61641783f0f7c"],"persistent_cta":["hide"],"_persistent_cta":["field_6375dc7c0b25c"],"show_popup":["1"],"_show_popup":["field_62b1aec56dcb5"],"solutions":[""],"_solutions":["field_61eac16edee33"],"solutions_category":[""],"_solutions_category":["field_61eac09d5e59c"],"therapeutic_area_icon":[""],"_therapeutic_area_icon":["field_62445225df5f2"],"therapeutic_areas":[""],"_therapeutic_areas":["field_61eac19284449"],"_yoast_wpseo_content_score":["30"],"_yoast_wpseo_focuskeywords":[""],"_yoast_wpseo_keywordsynonyms":[""],"_yoast_wpseo_estimated-reading-time-minutes":["2"],"cta_btn_text":["Get started"],"_cta_btn_text":["field_62984e409758b"],"cta_btn_url":["#popup-1"],"_cta_btn_url":["field_62984e699758c"],"cta_url_open_new_tab":["0"],"_cta_url_open_new_tab":["field_629dce361d7e6"],"cta_btn_style":["cta-1"],"_cta_btn_style":["field_62986b9c7c2ee"],"_ame_cpe_post_policy":["{\"accessProtection\":{\"active\":\"replace\"}}"],"popup_box_id":["popup-1"],"_popup_box_id":["field_62b1ab70ff7f5"],"_dp_original":["12972"],"_edit_last":["7"],"_edit_lock":["1753719883:7"],"_yoast_wpseo_focuskw":["Clinical Trial solutions for Pain Disorders"],"_yoast_wpseo_metadesc":["Discover how Clario Clinical Trial solutions for Pain Disorders elevate evidence-based decision-making with advanced data strategies."],"_yoast_wpseo_linkdex":["66"],"_yoast_indexnow_last_ping":["1753719799"]},"_links":{"self":[{"href":"https:\/\/clario.com\/wp-json\/wp\/v2\/therapeutic-areas\/12973","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/clario.com\/wp-json\/wp\/v2\/therapeutic-areas"}],"about":[{"href":"https:\/\/clario.com\/wp-json\/wp\/v2\/types\/therapeutic-areas"}],"up":[{"embeddable":true,"href":"https:\/\/clario.com\/wp-json\/wp\/v2\/therapeutic-areas\/5024"}],"wp:attachment":[{"href":"https:\/\/clario.com\/wp-json\/wp\/v2\/media?parent=12973"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/clario.com\/wp-json\/wp\/v2\/tags?post=12973"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}